Disminución de la respuesta T durante la fase de inmunosupresión de la sepsispor Staphylococcusaureus : rol de las células mieloides supresoras (MDSC) y la señalización por TNFR1
Sepsis is a disease with a great impact on public health because of its high rate of morbidity and mortality. Currently, S. aureus is the most frequently isolated pathogen in septic patients with documented bacterial infection. The events leading to the immunosuppression associated with S. aureus se...
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| Formato: | Tesis doctoral acceptedVersion |
| Lenguaje: | Español |
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Facultad de Farmacia y Bioquímica
2018
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| Acceso en línea: | http://repositoriouba.sisbi.uba.ar/gsdl/cgi-bin/library.cgi?a=d&c=posgraafa&cl=CL1&d=HWA_5765 http://repositoriouba.sisbi.uba.ar/gsdl/collect/posgraafa/index/assoc/HWA_5765.dir/5765.PDF |
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| Sumario: | Sepsis is a disease with a great impact on public health because of its high rate of morbidity and mortality. Currently, S. aureus is the most frequently isolated pathogen in septic patients with documented bacterial infection. The events leading to the immunosuppression associated with S. aureus sepsis have not been fully elucidated. Among the cell types that could be involved, recent studies have suggested that early expansion of MDSC is predictive of development of secondary nosocomial infections in septic patients, which suggests an important role for these cells in the immune suppression. In this context, the role that TNF-? and TNFR1 signaling could have in accumulation and function of MDSC is unknown.\nIn the present study, using a murine model of S. aureus sepsis of peritoneal origin, we demonstrated for the first time that MDSC participate in immunosuppression associated with S. aureus sepsis, and that TNF-? signaling through TNFR1 is critical in this process. Our findings will contribute to establish the potential of considering MDSC as a target for immunomodulatory therapies that complement conventional therapies in septic patients. |
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