SINTITUL-3
Administration of ketamine in combination with midazolam is currently recommended for induction of general anaesthesia in small animal surgery. The aim of this study was to analyse the pharmacological response of a ketamine-midazolam combination injected at different hours in dogs. The experience wa...
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| Autores principales: | , , , , |
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| Formato: | Artículo publishedVersion |
| Lenguaje: | Español |
| Publicado: |
Universidad de Buenos Aires. Facultad de Ciencias Veterinarias.
2003
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| Materias: | |
| Acceso en línea: | http://repositoriouba.sisbi.uba.ar/gsdl/cgi-bin/library.cgi?a=d&c=pveterinaria/invet&cl=CL1&d=HWA_4511 https://repositoriouba.sisbi.uba.ar/gsdl/collect/pveterinaria/invet/index/assoc/HWA_4511.dir/4511.PDF |
| Aporte de: |
| Sumario: | Administration of ketamine in combination with midazolam is currently recommended for induction of general anaesthesia in small animal surgery. The aim of this study was to analyse the pharmacological response of a ketamine-midazolam combination injected at different hours in dogs. The experience was conducted in June 2002. Six Beagle adult dogs (8.4 to 12.6 kg) from Facultad de Ciencias Veterinarias, UBA were administered intramuscularly ketamine ClH (10 mg/kg) and midazolam ClH (0.5 mg/kg) at 11.00 and 23.00 h (local hour), with a washout period of 3 weeks. Duration of pharmacological response (minutes) was recorded by visual assessment starting from the administration of the combination as follows: duration of latency period, preand post-recumbency ataxia, beginning, duration and end of recumbency, duration of total pharmacological response. Duration of post-recumbency ataxia (minutes) was significantly lower (p<0.05) for the 11.00 h group (median 9.78) when compared with the 23.00 h group (median 19.7). Results of this study indicate that time of administration may partially affect ketaminemidazolam pharmacological response in dogs.\n |
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