legales2011 1.indd
Paratuberculosis, caused by Mycobacterium avium subspecies paratuberculosis, is a chronic granulomatous enteric disease affecting ruminants. Our aim was to characterize systemic and local humoral responses of infected cows. Eleven cows were studied: six naturally infected (asymptomatic, symptomatic...
Guardado en:
| Autores principales: | , , , , |
|---|---|
| Formato: | Artículo publishedVersion |
| Lenguaje: | Español |
| Publicado: |
Universidad de Buenos Aires. Facultad de Ciencias Veterinarias.
2011
|
| Materias: | |
| Acceso en línea: | http://repositoriouba.sisbi.uba.ar/gsdl/cgi-bin/library.cgi?a=d&c=pveterinaria/invet&cl=CL1&d=HWA_3812 https://repositoriouba.sisbi.uba.ar/gsdl/collect/pveterinaria/invet/index/assoc/HWA_3812.dir/3812.PDF |
| Aporte de: |
| Sumario: | Paratuberculosis, caused by Mycobacterium avium subspecies paratuberculosis, is a chronic granulomatous enteric disease affecting ruminants. Our aim was to characterize systemic and local humoral responses of infected cows. Eleven cows were studied: six naturally infected (asymptomatic, symptomatic and terminal) and fi ve control. Total IgM and IgG and paratuberculosis-specifi c IgG subisotypes, from feces and serum, were assessed by ELISA. No differences were detected on the levels of total immunoglobulins in sera. Symptomatic cows showed signifi cative higher level of totals IgM and IgG, and specifi c-IgG in feces. IgG1 was the highest from sera of symptomatic and terminal. IgG3 was the highest specifi c immunoglobulin in sera and feces of asymptomatic. Our results showed total immunoglobulins levels in serum are not modifi ed by the infection. The increment of immunoglobulins in feces could be caused by the lesions of intestinal mucosa. The predominance of IgG1 in symptomatic period is related to the change toward Th2 profi le. The use of anti-IgG3 could improve the identifi cation of asymptomatic cows. |
|---|