Sistema cardiovascular y disfunción tiroidea en las diferentes etapas de la vida : participación del óxido nítrico
In this thesis work, at different rat ages, we are showing that thyroid hormones could modulate pacemaker heart activity through auricular nitric oxide system and, in this regulation is involved Akt pathway in perinatal ages. Hyperthyroidism increased ventricular nitric oxide synthesis which is Akt...
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| Formato: | Tesis doctoral acceptedVersion |
| Lenguaje: | Español |
| Publicado: |
Facultad de Farmacia y Bioquímica
2019
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| Acceso en línea: | http://repositoriouba.sisbi.uba.ar/gsdl/cgi-bin/library.cgi?a=d&c=posgraafa&cl=CL1&d=HWA_3029 http://repositoriouba.sisbi.uba.ar/gsdl/collect/posgraafa/index/assoc/HWA_3029.dir/3029.PDF |
| Aporte de: |
| Sumario: | In this thesis work, at different rat ages, we are showing that thyroid hormones could modulate pacemaker heart activity through auricular nitric oxide system and, in this regulation is involved Akt pathway in perinatal ages. Hyperthyroidism increased ventricular nitric oxide synthesis which is Akt pathway independent. This finding was accompanied by a left ventricular remodeling that was different in age and gender. On the other hand, thyroid hormones effects on the mtNOS activity are dependent on age. Mitochondrial nitric oxide bioavailability changes could modify ATP synthesis and, as a result, pacemaker heart activity and myocardial contractile function. Akt pathway is not be involved in these effects. During hypovolaemic state, the immediate hypotension observed was nitric oxide system and thyroid state independent but it was age dependent. In the last phase of haemorrhage, nitric oxide could modulate arterial pressure. Nitric oxide bioavailability induced a heterogeneous and dynamic nitric oxide synthase activation that it was age and thyroid state independent. |
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