Dimorfismo sexual en el perfil de transportadores renales, la homeostasis electrolítica y la regulación de la presión arterial
Our understanding of disease processes and treatments begins with preclinical\nstudies that use animals and/or cell cultures. Most preclinical biomedical research,\nhowever, has been conducted without taking sex into account as an important variable.\nMale and female Sprague Dawley rats (SD) and C57...
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| Formato: | Tesis doctoral acceptedVersion |
| Lenguaje: | Español |
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Facultad de Farmacia y Bioquímica
2018
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| Acceso en línea: | http://repositoriouba.sisbi.uba.ar/gsdl/cgi-bin/library.cgi?a=d&c=posgraafa&cl=CL1&d=HWA_2933 http://repositoriouba.sisbi.uba.ar/gsdl/collect/posgraafa/index/assoc/HWA_2933.dir/2933.PDF |
| Aporte de: |
| Sumario: | Our understanding of disease processes and treatments begins with preclinical\nstudies that use animals and/or cell cultures. Most preclinical biomedical research,\nhowever, has been conducted without taking sex into account as an important variable.\nMale and female Sprague Dawley rats (SD) and C57Bl/6J mice were studied at baseline\nand showed a sexual dimorphic pattern of Na+ and K+ transporters and channels along\nthe nephron. A lower fractional Na+ and water reabsorption in the female proximal tubule\npromotes a greater reabsorption along the distal nephron, which facilitates K+ secretion\nand sets plasma K+ at a lower level compared to males. Moreover, in SD rats the\nhypertensive response to Ang II was similar in both sexes but the mechanisms involved\nshowed sexual dimorphism. The K+-rich diet blunted the stimulation of NCC in males and\nNKCC2 in females, thus promoting Na+ excretion. In summary, sexual dimorphism in the\ndevelopment of hypertension should be considered when preventing, diagnosing and\ntreating the disease. |
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