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The aim of this thesis was to develop and characterize topical formulations, for use on skin and buccal mucous, which including a combination of Lippia turbinata and Lippia alba extracts with antibacterial and anti-inflammatory activity. The hydroalcoholic leaching method allowed obtaining extracts...
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| Formato: | Tesis doctoral acceptedVersion |
| Lenguaje: | Español |
| Publicado: |
Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica
2018
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| Acceso en línea: | http://repositoriouba.sisbi.uba.ar/gsdl/cgi-bin/library.cgi?a=d&c=posgraafa&cl=CL1&d=HWA_2821 https://repositoriouba.sisbi.uba.ar/gsdl/collect/posgraafa/index/assoc/HWA_2821.dir/2821.PDF |
| Aporte de: |
| Sumario: | The aim of this thesis was to develop and characterize topical formulations, for use on skin and buccal mucous, which including a combination of Lippia turbinata and Lippia alba extracts with antibacterial and anti-inflammatory activity. The hydroalcoholic leaching method allowed obtaining extracts with 70% ethanol and the extracts of both species were evaluated in their physicochemical properties and biological activities already mentioned. Gels and emulgels were prepared for application on skin, and films for application on buccal mucosa. The formulations were characterized regarding their organoleptic characteristics, physical-chemical properties, mechanical properties, antibacterial activity and in vitro permeation. Also, a microbiological control was made. Then, the formulations were subjected to stability studies in different conditions of temperature and humidity. The emulgels were not stable. Within gels evaluated, the formulation containing Sepigel at 4% (w/w) presented better characteristics. Concerning the film-type formulations, HPMC polymer at 1% (w/w) was the most suitable for the proposed purpose. The results obtained demonstrated the feasibility of to include the extract in the gel and films formulations assayed, achieving the preservation of the antibacterial effect of the extract and maintaining stability over time without the use of antimicrobial preservatives for 18 months. |
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