Participación de polifenoles derivados de la uva en la adipogénesis y angiogénesis, y su asociación con la inflamación del tejido adiposo y patologías asociadas
Obesity is associated with adipocyte hypertrophy, interrupted adipogenesis, and low-grade chronic inflammation. The increase of adiposity mainly visceral type is associated with the development and progression of metabolic and vascular complications. The alteration of normal adipocytes differentiati...
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| Formato: | Tesis doctoral acceptedVersion |
| Lenguaje: | Español |
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Facultad de Farmacia y Bioquímica
2019
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| Acceso en línea: | http://repositoriouba.sisbi.uba.ar/gsdl/cgi-bin/library.cgi?a=d&c=posgraafa&cl=CL1&d=HWA_2804 http://repositoriouba.sisbi.uba.ar/gsdl/collect/posgraafa/index/assoc/HWA_2804.dir/2804.PDF |
| Aporte de: |
| Sumario: | Obesity is associated with adipocyte hypertrophy, interrupted adipogenesis, and low-grade chronic inflammation. The increase of adiposity mainly visceral type is associated with the development and progression of metabolic and vascular complications. The alteration of normal adipocytes differentiation is attributed to macrophages recruitment and increased pro-inflammatory cytokines release in adipose tissue (AT). Polyphenols are bioactive compounds of vegetable origin that have been shown to have potential beneficial effects on health, including anti-inflammatory effects. Our hypothesis suggests that grape pomace (GP) polyphenols intervention attenuates metabolic and vascular disorders associated with metabolic syndrome (MS) and AT adiposity and inflammation in part, by stimulating AT healthy expansion. It was observed that GP intervention restores the alteration of metabolic variables and prevents the incidence and severity of arrhythmias in a MS model. On the other hand, the grape pomace extract and the flavonoid quercetin stimulate the expression of proteins involved in AT adipogenesis and angiogenesis associated with a reduction in inflammation. Our results highlight the use of GP bioactive compounds for the prevention / attenuation of pathologies associated with increased adiposity |
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