Desarrollo de biomateriales como sistemas de liberación locales para el tratamiento de enfermedades orales
Different materials have distinct surface and bulk characteristics; each of them potentially useful for the treatment of a particular wound or disease. By studying those materials, the reader will have a broad panorama of the possibilities a particular material can offer, regarding its ability to su...
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| Formato: | Tesis doctoral acceptedVersion |
| Lenguaje: | Español |
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Facultad de Farmacia y Bioquímica
2018
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| Acceso en línea: | http://repositoriouba.sisbi.uba.ar/gsdl/cgi-bin/library.cgi?a=d&c=posgraafa&cl=CL1&d=HWA_2710 http://repositoriouba.sisbi.uba.ar/gsdl/collect/posgraafa/index/assoc/HWA_2710.dir/2710.PDF |
| Aporte de: |
| Sumario: | Different materials have distinct surface and bulk characteristics; each of them potentially useful for the treatment of a particular wound or disease. By studying those materials, the reader will have a broad panorama of the possibilities a particular material can offer, regarding its ability to support tissue regeneration or local drug delivery. This thesis covers recent advances made towards the development of biomaterials aimed to support regenerative processes and drug delivery. Indeed, we highlight ultrastructure, rheological properties, cytocompatibility, release kinetics and biological properties of different biomaterials for a specific biomedical application. In this context, the focus is made on collagen, chitosan and silica which are key representatives of a protein, a polysaccharide and an inorganic material usually employed as biomaterials. Particularly, this thesis presents an overview of their potential therapeutics in the treatment of disorders within the oral mucosa and tooth supporting tissues. Finally, the importance of material characterization, in vitro and in vivo studies as an adequate guidance for biomaterial design and development is highlighted. |
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