Rol de la proteína Sbi en la inducción de respuesta inflamatoria y en la patogenia de las infecciones localizadas y sistémicas por Staphylococcus aureus
Staphylococcus aureus is an opportunistic microorganism and its success as a pathogen relies on its multiple virulence factors. S. aureus proteins SpA and Sbi bind to IgG and have high sequence identity in their binding domains. Both participate in different evasion mechanisms but so far only SpA ha...
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| Formato: | Tesis doctoral acceptedVersion |
| Lenguaje: | Español |
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Facultad de Farmacia y Bioquímica
2017
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| Acceso en línea: | http://repositoriouba.sisbi.uba.ar/gsdl/cgi-bin/library.cgi?a=d&c=posgraafa&cl=CL1&d=HWA_2004 http://repositoriouba.sisbi.uba.ar/gsdl/collect/posgraafa/index/assoc/HWA_2004.dir/2004.PDF |
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| Sumario: | Staphylococcus aureus is an opportunistic microorganism and its success as a pathogen relies on its multiple virulence factors. S. aureus proteins SpA and Sbi bind to IgG and have high sequence identity in their binding domains. Both participate in different evasion mechanisms but so far only SpA has been implicated in inducing an inflammatory response. This study demonstrated that Sbisimilarly to SpA induces inflammatory mediators by triggering signaling through the TNF-? receptor type 1 and the epidermal growth factor receptor. Furthermore, it was demonstrated that during S. aureussystemic infection of peritoneal origin SpA and Sbi both contribute to the development of bacteremia, whereas only Sbi is critical for bacterial clearance in the lung. During skin infections, however, both proteins have a protective role driving the development of delimited abscesses and local induction of IL-6. SpA seems to be more critical than Sbi participating in the local induction of IL-1?, TNF-?, CXCL-1 yCXCL-10. The expression of both Sbi and SpA enables the development of smaller skin lesions, less bacterial dissemination and better resolution of the infection. The results obtained during this study also indicate that the roleof a virulence factor in pathogenesis highly depends on the type of infection considered. |
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