Staphylococcus aureus meticilino resistente adquirido en la comunidad : epidemiología molecular y patogenicidad de los principales clones circulantes en Argentina
Community-acquired methicillin resistant Staphylococcus aureus (CA-MRSA) is the leading cause of skin and skin structures infections, although it can produce invasive infections in patients without contact with the health system.\nFrom two national multicenter studies with 19 participating hospitals...
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| Formato: | Tesis doctoral acceptedVersion |
| Lenguaje: | Español |
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Facultad de Farmacia y Bioquímica
2017
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| Acceso en línea: | http://repositoriouba.sisbi.uba.ar/gsdl/cgi-bin/library.cgi?a=d&c=posgraafa&cl=CL1&d=HWA_1962 http://repositoriouba.sisbi.uba.ar/gsdl/collect/posgraafa/index/assoc/HWA_1962.dir/1962.PDF |
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| Sumario: | Community-acquired methicillin resistant Staphylococcus aureus (CA-MRSA) is the leading cause of skin and skin structures infections, although it can produce invasive infections in patients without contact with the health system.\nFrom two national multicenter studies with 19 participating hospitals, which included patients over 14 years old with invasive and noninvasive infections, the emergence of a prevalent clone, MRSA ST30-IVc, was documented in the community in replacement of ST5-IVa clone. In addition, it was statistically associated with a higher production of invasive infection.\nThe ST30-IVc clone exhibited higher virulence in two experimental infection models compared to ST5-IVa, as it presented better replication in the subcutaneous niche and greater capacity of invasion from the primary focus. In addition it caused greater damage in the bone tissue and a higher replication.\nThe specific virulence genes profile of ST30-IVc, given by genes encoding proteins that bind fibronectin, collagen and bone sialoprotein, coupled with a likely higher production of the FnbA protein could explain the greater virulence in both models and association with an increased occurrence of invasive infection. |
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