Hipovolemia por restricción de agua y moduladores según avanza la edad
The results in this investigation project show that nitric oxide system is involved in cardiac function modulation and renal balance of water during a hypovolemic state induced by a long term water restriction, in young and adult rats. Cardiac and renal structural and functional changes induced by o...
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| Formato: | Tesis doctoral acceptedVersion |
| Lenguaje: | Español |
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Facultad de Farmacia y Bioquímica
2016
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| Acceso en línea: | http://repositoriouba.sisbi.uba.ar/gsdl/cgi-bin/library.cgi?a=d&c=posgraafa&cl=CL1&d=HWA_1453 http://repositoriouba.sisbi.uba.ar/gsdl/collect/posgraafa/index/assoc/HWA_1453.dir/1453.PDF |
| Aporte de: |
| Sumario: | The results in this investigation project show that nitric oxide system is involved in cardiac function modulation and renal balance of water during a hypovolemic state induced by a long term water restriction, in young and adult rats. Cardiac and renal structural and functional changes induced by osmotic stress would be compensated with modifications in NO bioavailability and NOS-caveolin interactions with in these organs. Renal NO system affects AQP2 redistribution along renal medulla resulting in a lower capacity of urine concentration in adult rats. These observations emphasize the role of cardiac and renal NO system during hidrosaline unbalance induced by water restriction during the natural aging process. |
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