Exposición cutánea a la radiación ultravioleta : implicancias sobre funciones del sistema inmune
The skin is an organ constituted by different cell types, many of which have immunological\nfunctions. Moreover, it is the organ most exposed to UV radiation (UVR) contained within\nthe sunlight. This exposure may lead to a systemic immunosuppression. However, cutaneous\nexposure to UVR also have be...
Guardado en:
| Autor principal: | |
|---|---|
| Otros Autores: | |
| Formato: | Tesis doctoral acceptedVersion |
| Lenguaje: | Español |
| Publicado: |
Facultad de Farmacia y Bioquímica
2016
|
| Materias: | |
| Acceso en línea: | http://repositoriouba.sisbi.uba.ar/gsdl/cgi-bin/library.cgi?a=d&c=posgraafa&cl=CL1&d=HWA_1423 http://repositoriouba.sisbi.uba.ar/gsdl/collect/posgraafa/index/assoc/HWA_1423.dir/1423.PDF |
| Aporte de: |
| Sumario: | The skin is an organ constituted by different cell types, many of which have immunological\nfunctions. Moreover, it is the organ most exposed to UV radiation (UVR) contained within\nthe sunlight. This exposure may lead to a systemic immunosuppression. However, cutaneous\nexposure to UVR also have beneficial effects. The aim of this thesis was to comparatively\nevaluate the effects of cutaneous exposure to a single high UV dose (shUVd) and repetitive\nlow UV doses (rlUVd) on innate and adaptive immune response. Exposure to a shUVd lead to\na marked inflammation, with a defective adaptive immune response; whereas exposure to\nrlUVd produced the opposite effect, without any sign of inflammation, a reinforce of the\nepithelial barrier and a systemic immunestimulation. Contrasting with these results, when a\nStaphylococcus aureus infectious challenge was performed on irradiated animals, an absence\nof alterations in the response to the pathogen was observed in shUVd-exposed animals, while\nrlUVd-exposed ones exhibited a defective control of the infection allowing a greater\ndissemination of the infection. The present work demonstrates that cutaneous exposure to\nUVR may lead to different modifications of the immune response, both harmful and\nbeneficial |
|---|