Mecanismos responsables de las acciones vasculares del péptido natriurético tipo C : evaluación de los efectos beneficiosos de éste péptido sobre las alteraciones asociadas a la hipertensión arterial
C-type natriuretic peptide (CNP) is involved in cardiovascular homeostasis\nregulation, and it could play a beneficial role in hypertension.\nThe aims of this work were to study the in vivo and in vitro effects of CNP on\nvascular function. Evaluate if there are alterations in CNP-induced effects an...
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| Formato: | Tesis doctoral acceptedVersion |
| Lenguaje: | Español |
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Facultad de Farmacia y Bioquímica
2015
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| Acceso en línea: | http://repositoriouba.sisbi.uba.ar/gsdl/cgi-bin/library.cgi?a=d&c=posgraafa&cl=CL1&d=HWA_1412 http://repositoriouba.sisbi.uba.ar/gsdl/collect/posgraafa/index/assoc/HWA_1412.dir/1412.PDF |
| Aporte de: |
| Sumario: | C-type natriuretic peptide (CNP) is involved in cardiovascular homeostasis\nregulation, and it could play a beneficial role in hypertension.\nThe aims of this work were to study the in vivo and in vitro effects of CNP on\nvascular function. Evaluate if there are alterations in CNP-induced effects and the\nmechanisms involved, in hypertension. Evaluate the impact of CNP chronic\nadministration on blood pressure (BP) and target organ damage in this disease.\nWe observed that CNP stimulates the release of nitric oxide (NO) and\nprostacyclin, in addition to stimulates cell cycle without inducing changes in\nendothelial cell viability. Endothelial NO and potassium channels opening in smooth\nmuscle cells, mediate the vasodilator effect of CNP in the aorta of normotensive and\nhypertensive rats. However, both pathways are impaired in hypertension. Chronic\nadministration of CNP decreases BP and oxidative stress, increases vasodilator\nresponse and induces changes in aorta remodeling. Through these effects, CNP\nimproves the integrity of the vessel wall and may be beneficial in this model of\nhypertension. |
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