Efectos cardiovasculares y renales del tratamiento crónico con péptido natriurético atrial en ratas espontáneamente hipertensas : participación del sistema del óxido nítrico
Atrial natriuretic peptide (ANP) is a hypotensive and natriuretic factor involved in the regulation of cardiovascular and renal function. This thesis studied the cardiovascular and renal effects of an infusion of ANP (100ng/h) for 14 days to young adult male and female spontaneously hypertensive rat...
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| Formato: | Tesis doctoral acceptedVersion |
| Lenguaje: | Español |
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Facultad de Farmacia y Bioquímica
2015
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| Acceso en línea: | http://repositoriouba.sisbi.uba.ar/gsdl/cgi-bin/library.cgi?a=d&c=posgraafa&cl=CL1&d=HWA_1163 http://repositoriouba.sisbi.uba.ar/gsdl/collect/posgraafa/index/assoc/HWA_1163.dir/1163.PDF |
| Aporte de: |
| Sumario: | Atrial natriuretic peptide (ANP) is a hypotensive and natriuretic factor involved in the regulation of cardiovascular and renal function. This thesis studied the cardiovascular and renal effects of an infusion of ANP (100ng/h) for 14 days to young adult male and female spontaneously hypertensive rats (SHR). We determined whether there were differences between sexes.\nANP decreased blood pressure by increasing diuresis and natriuresis; reduced myocyte size, the number of apoptotic cells in heart and kidney and the content of interstitial and perivascular collagen in heart, kidney and aorta; it stimulated NO system activity and decreased the oxidative status in heart and kidney.\nThe beneficial effects of ANP on cardiovascular and renal morphology would be higher in males than in females SHR. These could be related with the fact that female SHR showed lower blood pressure values and cardiovascular and kidney damage, as well as increased NOS activity and antioxidant capacity in these tissues than males.\nThe results of this study suggest the potential utility of chronic ANP treatment for preventing the cardiovascular and renal damage that these animals exhibit with the development of hypertension. |
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