Estudio prospectivo de factores de riesgo asociados a insulino-resistencia y al desarrollo de enfermedad cardiovascular
Cardiovascular disease (CVD) is the leading cause of death in the West; obesity, especially abdominal (AO) and the inflammatory condition is associated with the presence of CVD and insulin resistance (IR). Adiponectin, considered an insulin sensitizer has anti-atherogenic and anti-inflammatory effec...
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| Formato: | Tesis doctoral acceptedVersion |
| Lenguaje: | Español |
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Facultad de Farmacia y Bioquímica
2015
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| Acceso en línea: | http://repositoriouba.sisbi.uba.ar/gsdl/cgi-bin/library.cgi?a=d&c=posgraafa&cl=CL1&d=HWA_1160 http://repositoriouba.sisbi.uba.ar/gsdl/collect/posgraafa/index/assoc/HWA_1160.dir/1160.PDF |
| Aporte de: |
| Sumario: | Cardiovascular disease (CVD) is the leading cause of death in the West; obesity, especially abdominal (AO) and the inflammatory condition is associated with the presence of CVD and insulin resistance (IR). Adiponectin, considered an insulin sensitizer has anti-atherogenic and anti-inflammatory effects. The relationship between the presence of IR and risk factors associated with morbidity and mortality from CVD by a prospective cohort was studied. 315 individuals (247 females (47.6 ± 9.1 years) and 68 males (47.1 ± 9.2 years)) were studied for five years. A subgroup of 70 subjects for the study of gene and adiponectin receptors for molecular biology included. Prevalence of overweight (38.7%) and obesity (27.3%) associated with an atherogenic lipid profile was found. 24.1% of individuals had metabolic syndrome (MS) being col-HDL decreased the most common parameter; according HOMA IR was 18%. Obesity increased from 2007 to 2011 by 8.1%. Over 5 years, 58 individuals developed diabetes and 9 IR (type 2 diabetes mellitus). Of the variables analyzed, AO predicted IR and obesity predicted T2DM. 45.7% of individuals had decreased adiponectin. Only in women serum adiponectin explained the IR independently. In the analysis of gene sequences ADIPOQ a SNP found not described in the SNP database (dbSNP) at -11 348 G> T position of the promoter region at a frequency of 38% was associated with lower values of circulating adiponectin. The GG genotype of ADIPOR2 SNP rs1029629 showed significant association with IR and with decreased circulating adiponectin. |
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