Crystal packing modifies ligand binding affinity : The case of aldose reductase
The relationship between the structures of protein-ligand complexes existing in the crystal and in solution, essential in the case of fragment-based screening by X-ray crystallography (FBS-X), has been often an object of controversy. To address this question, simultaneous co-crystallization and soak...
Guardado en:
| Autores principales: | Cousido-Siah, Alexandra, Petrova, Tatiana, Hazemann, Isabelle, Mitschler, André, Ruiz, Francesc X., Howard, Eduardo Ignacio, Ginell, Stepahn, Atmanene, Cédric, Van Dorsselaer, Alain, Sanglier-Cienférani, Sarah, Joachimiak, Andrzej, Podjarny, Alberto |
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| Formato: | Articulo Preprint |
| Lenguaje: | Inglés |
| Publicado: |
2012
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| Materias: | |
| Acceso en línea: | http://sedici.unlp.edu.ar/handle/10915/96851 https://ri.conicet.gov.ar/11336/83350 https://onlinelibrary.wiley.com/doi/full/10.1002/prot.24136 http://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC4671318&blobtype=pdf https://www.ncbi.nlm.nih.gov/pubmed/22752989 |
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