Substrate engagement of integrins α5 β1 and αv β3 is necessary, but not sufficient, for high directional persistence in migration on fibronectin

The interplay between specific integrin-mediated matrix adhesion and directional persistence in cell migration is not well understood. Here, we characterized fibroblast adhesion and migration on the extracellular matrix glycoproteins fibronectin and vitronectin, focusing on the role of α5 β1 and αv...

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Detalles Bibliográficos
Autores principales: Missirlis, Dimitris, Haraszti, Tamás, Scheele, Catharina v. C., Wiegand, Tina, Díaz, Carolina, Neubauer, Stefanie, Rechenmacher, Florian, Kessler, Horst, Spatz, Joachim P.
Formato: Articulo
Lenguaje:Inglés
Publicado: 2016
Materias:
Química
Focal adhesion
Integrin signaling
Fibronectin
Migration
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/96483
https://ri.conicet.gov.ar/11336/49069
https://www.nature.com/articles/srep23258
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata

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