Structure and pharmacological actions of phyllocaerulein, a caerulein-like nonapeptide: its occurrence in extracts of the skin of Phyllomedusa sauvagei and related Phyllomedusa species
The present communication gives an account of the isolation, structure and pharmacological properties of the caerulein-like polypeptide occurring in the skin of Phyllomedusa sauvagei from north-western regions of Argentina. For the new polypeptide, a nonapeptide closely resembling caerulein both fro...
Guardado en:
| Autores principales: | , , , , , |
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| Formato: | Articulo |
| Lenguaje: | Inglés |
| Publicado: |
1969
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| Materias: | |
| Acceso en línea: | http://sedici.unlp.edu.ar/handle/10915/90249 |
| Aporte de: |
| Sumario: | The present communication gives an account of the isolation, structure and pharmacological properties of the caerulein-like polypeptide occurring in the skin of Phyllomedusa sauvagei from north-western regions of Argentina. For the new polypeptide, a nonapeptide closely resembling caerulein both from a biological and chemical point of view, the name phyllocaerulein is proposed. This paper also describes the occurrence of phyllocaerulein or related peptides in the skin of other Phyllomedusa species.
A complete description of methods used in the isolation of phyllocaerulein as well as in the determination of amino-acid composition and amino-acid sequence of the polypeptide may be found in a preceding paper dealing with the isolation and the amino acid sequence of caerulein (Anastasi, Erspamer & Endean, 1968 ; Anastasi, 1969). |
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