Protein Kinase C Epsilon Cooperates with PTEN Loss for Prostate Tumorigenesis through the CXCL13-CXCR5 Pathway

PKCε, an oncogenic member of the PKC family, is aberrantly overexpressed in epithelial cancers. To date, little is known about functional interactions of PKCε with other genetic alterations, as well as the effectors contributing to its tumorigenic and metastatic phenotype. Here, we demonstrate that...

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Detalles Bibliográficos
Autores principales: Garg, R., Blando, Jorge M., Pérez, Carlos J., Abba, Martín Carlos, Benavides, Fernando, Kazanietz, Marcelo
Formato: Articulo
Lenguaje:Inglés
Publicado: 2017
Materias:
Ciencias Médicas
CXCL13
CXCR5
migration
NF-κB
PKCε
proliferation
prostate cancer
PTEN
transgenic mice
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/87748
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata

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