Diversity of fate outcomes in cell pairs under lateral inhibition

Cell fate determination by lateral inhibition via Notch/Delta signalling has been extensively studied. Most formalised models consider Notch/Delta interactions in fields of cells, with parameters that typically lead to symmetry breaking of signalling states between neighbouring cells, commonly resul...

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Autores principales: Guisoni, Nara Cristina, Martinez-Corral, R., Garcia-Ojalvo, J., de Navascués, J.
Formato: Articulo
Lenguaje:Inglés
Publicado: 2017
Materias:
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/87428
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id I19-R120-10915-87428
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Ciencias Exactas
Física
Intestinal stem cells
Lateral inhibition
Neutral competition
Notch-Delta signalling
Symmetric cell division
spellingShingle Ciencias Exactas
Física
Intestinal stem cells
Lateral inhibition
Neutral competition
Notch-Delta signalling
Symmetric cell division
Guisoni, Nara Cristina
Martinez-Corral, R.
Garcia-Ojalvo, J.
de Navascués, J.
Diversity of fate outcomes in cell pairs under lateral inhibition
topic_facet Ciencias Exactas
Física
Intestinal stem cells
Lateral inhibition
Neutral competition
Notch-Delta signalling
Symmetric cell division
description Cell fate determination by lateral inhibition via Notch/Delta signalling has been extensively studied. Most formalised models consider Notch/Delta interactions in fields of cells, with parameters that typically lead to symmetry breaking of signalling states between neighbouring cells, commonly resulting in salt-and-pepper fate patterns. Here, we consider the case of signalling between isolated cell pairs, and find that the bifurcation properties of a standard mathematical model of lateral inhibition can lead to stable symmetric signalling states. We apply this model to the adult intestinal stem cell (ISC) of Drosophila, the fate of which is stochastic but dependent on the Notch/Delta pathway. We observe a correlation between signalling state in cell pairs and their contact area. We interpret this behaviour in terms of the properties of our model in the presence of population variability in contact areas, which affects the effective signalling threshold of individual cells. Our results suggest that the dynamics of Notch/Delta signalling can contribute to explain stochasticity in stem cell fate decisions, and that the standard model for lateral inhibition can account for a wider range of developmental outcomes than previously considered.
format Articulo
Articulo
author Guisoni, Nara Cristina
Martinez-Corral, R.
Garcia-Ojalvo, J.
de Navascués, J.
author_facet Guisoni, Nara Cristina
Martinez-Corral, R.
Garcia-Ojalvo, J.
de Navascués, J.
author_sort Guisoni, Nara Cristina
title Diversity of fate outcomes in cell pairs under lateral inhibition
title_short Diversity of fate outcomes in cell pairs under lateral inhibition
title_full Diversity of fate outcomes in cell pairs under lateral inhibition
title_fullStr Diversity of fate outcomes in cell pairs under lateral inhibition
title_full_unstemmed Diversity of fate outcomes in cell pairs under lateral inhibition
title_sort diversity of fate outcomes in cell pairs under lateral inhibition
publishDate 2017
url http://sedici.unlp.edu.ar/handle/10915/87428
work_keys_str_mv AT guisoninaracristina diversityoffateoutcomesincellpairsunderlateralinhibition
AT martinezcorralr diversityoffateoutcomesincellpairsunderlateralinhibition
AT garciaojalvoj diversityoffateoutcomesincellpairsunderlateralinhibition
AT denavascuesj diversityoffateoutcomesincellpairsunderlateralinhibition
bdutipo_str Repositorios
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