Abortive and propagating intracellular calcium waves: Analysis from a hybrid model

The functional properties of inositol(1,4,5)-triphosphate (IP<inf>3</inf>) receptors allow a variety of intracellular Ca2+ phenomena. In this way, global phenomena, such as propagating and abortive Ca2+ waves, as well as local events such as puffs, have been observed. Several experimenta...

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Detalles Bibliográficos
Autores principales: Guisoni, Nara Cristina, Ferrero, Paola Viviana, Layana, Carla, Diambra, Luis Aníbal
Formato: Articulo
Lenguaje:Inglés
Publicado: 2015
Materias:
Ciencias Exactas
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/87261
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-87261
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Ciencias Exactas
spellingShingle Ciencias Exactas
Guisoni, Nara Cristina
Ferrero, Paola Viviana
Layana, Carla
Diambra, Luis Aníbal
Abortive and propagating intracellular calcium waves: Analysis from a hybrid model
topic_facet Ciencias Exactas
description The functional properties of inositol(1,4,5)-triphosphate (IP<inf>3</inf>) receptors allow a variety of intracellular Ca2+ phenomena. In this way, global phenomena, such as propagating and abortive Ca2+ waves, as well as local events such as puffs, have been observed. Several experimental studies suggest that many features of global phenomena (e.g., frequency, amplitude, speed wave) depend on the interplay of biophysical processes such as diffusion, buffering, efflux and influx rates, which in turn depend on parameters such as buffer concentration, Ca2+ pump density, cytosolic IP<inf>3</inf> level, and intercluster distance. Besides, it is known that cells are able to modify some of these parameters in order to regulate the Ca2+ signaling. By using a hybrid model, we analyzed different features of the hierarchy of calcium events as a function of two relevant parameters for the calcium signaling, the intercluster distance and the pump strength or intensity. In the space spanned by these two parameters, we found two modes of calcium dynamics, one dominated by abortive calcium waves and the other by propagating waves. Smaller distances between the release sites promote propagating calcium waves, while the increase of the efflux rate makes the transition from propagating to abortive waves occur at lower values of intercluster distance. We determined the frontier between these two modes, in the parameter space defined by the intercluster distance and the pump strength. Furthermore, we found that the velocity of simulated calcium waves accomplishes Luther's law, and that an effective rate constant for autocatalytic calcium production decays linearly with both the intercluster distance and the pump strength.
format Articulo
Articulo
author Guisoni, Nara Cristina
Ferrero, Paola Viviana
Layana, Carla
Diambra, Luis Aníbal
author_facet Guisoni, Nara Cristina
Ferrero, Paola Viviana
Layana, Carla
Diambra, Luis Aníbal
author_sort Guisoni, Nara Cristina
title Abortive and propagating intracellular calcium waves: Analysis from a hybrid model
title_short Abortive and propagating intracellular calcium waves: Analysis from a hybrid model
title_full Abortive and propagating intracellular calcium waves: Analysis from a hybrid model
title_fullStr Abortive and propagating intracellular calcium waves: Analysis from a hybrid model
title_full_unstemmed Abortive and propagating intracellular calcium waves: Analysis from a hybrid model
title_sort abortive and propagating intracellular calcium waves: analysis from a hybrid model
publishDate 2015
url http://sedici.unlp.edu.ar/handle/10915/87261
work_keys_str_mv AT guisoninaracristina abortiveandpropagatingintracellularcalciumwavesanalysisfromahybridmodel
AT ferreropaolaviviana abortiveandpropagatingintracellularcalciumwavesanalysisfromahybridmodel
AT layanacarla abortiveandpropagatingintracellularcalciumwavesanalysisfromahybridmodel
AT diambraluisanibal abortiveandpropagatingintracellularcalciumwavesanalysisfromahybridmodel
bdutipo_str Repositorios
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