Stability of proICA512/IA-2 and its targeting to insulin secretory granules require β4-sheet-mediated dimerization of its ectodomain in the endoplasmic reticulum

The type 1 diabetes autoantigen ICA512/IA-2/RPTPN is a receptor protein tyrosine phosphatase of the insulin secretory granules (SGs) which regulates the size of granule stores, possibly via cleavage/signaling of its cytosolic tail. The role of its extracellular region remains unknown. Structural stu...

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Detalles Bibliográficos
Autores principales: Torkko, Juha M, Primo, M. Evangelina, Dirkx, Ronald, Friedrich, Anne, Viehrig, Antje, Vergari, Elisa, Borgonovo, Barbara, Sönmez, Anke, Wegbrod, Carolin, Lachnit, Martina, Münster, Carla, Sica, Mauricio Pablo, Ermácora, Mario Roberto, Solimena, Michele
Formato: Articulo
Lenguaje:Inglés
Publicado: 2015
Materias:
Biología
Insulin
Protein tyrosine kinase
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/86902
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata

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