DMBA induced mouse mammary tumors display high incidence of activating Pik3ca<sup>H1047</sup> and loss of function Pten mutations

Controversy always existed on the utility of chemically induced mouse mammary carcinogenesis models as valid equivalents for the study of human breast cancer. Here, we performed whole exome and RNA sequencing on long latency mammary tumors (218 ± 27 days) induced by the carcinogen 7,12-Dimethylbenza...

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Detalles Bibliográficos
Autores principales: Abba, Martín Carlos, Zhong, Yi, Lee, Jaeho, Kil, Hyunsuk, Lu, Yue, Takata, Yoko, Simper, Melissa S., Gaddis, Sally, Shen, Jianjun, Aldaz, C. Marcelo
Formato: Articulo
Lenguaje:Inglés
Publicado: 2016
Materias:
Ciencias Médicas
DMBA
Mammary tumors
MPA
Pik3ca
Pten
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/86650
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata

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