Pseudoexons provide a mechanism for allele-specific expression of APC in familial adenomatous polyposis

Allele-specific expression (ASE) of the Adenomatous Polyposis Coli (APC) gene occurs in up to one-third of families with adenomatous polyposis (FAP) that have screened mutation-negative by conventional techniques. To advance our understanding of the genomic basis of this phenomenon, 54 APC mutation-...

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Detalles Bibliográficos
Autores principales: Nieminen, Taina T., Pavicic, Walter Hernán, Porkka, Noora, Kankainen, Matti, Järvinen, Heikki J., Lepistö, Anna, Peltomäki, Päivi
Formato: Articulo
Lenguaje:Inglés
Publicado: 2016
Materias:
Ciencias Médicas
Allele-specific expression
APC
Familial adenomatous polyposis
Pseudoexon
RNA-seq
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/86342
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata

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