Defective removal of ribonucleotides from DNA promotes systemic autoimmunity

Genome integrity is continuously challenged by the DNA damage that arises during normal cell metabolism. Biallelic mutations in the genes encoding the genome surveillance enzyme ribonuclease H2 (RNase H2) cause Aicardi-Goutières syndrome (AGS), a pediatric disorder that shares features with the auto...

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Guardado en:
Detalles Bibliográficos
Autor principal: Chara, Osvaldo
Formato: Articulo
Lenguaje:Inglés
Publicado: 2015
Materias:
Biología
Aicardi Syndrome
Mutation
Syndrome AGS
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/86202
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata

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