Seroprevalence of <i>Triatoma virus</i> (<i>Dicistroviridae</i>: <i>Cripaviridae</i>) antibodies in Chagas disease patients

Background: Chagas disease is caused by <i>Trypanosoma cruzi</i>, and humans acquire the parasite by exposure to contaminated feces from hematophagous insect vectors known as triatomines. Triatoma virus (TrV) is the sole viral pathogen of triatomines, and is transmitted among insects thr...

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Autores principales: Echeverría, María Gabriela, Martí, Gerardo Aníbal, Susevich, María Laura, Rabinovich, Jorge Eduardo
Formato: Articulo
Lenguaje:Inglés
Publicado: 2015
Materias:
Ciencias Naturales
Ciencias Veterinarias
Ciencias Médicas
Biological control
Chagas disease
Dicistroviridae
Mathematical model
Passive viral exposure
Triatoma virus
Triatomines
Trypanosoma cruzi
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/86187
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-86187
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Ciencias Naturales
Ciencias Veterinarias
Ciencias Médicas
Biological control
Chagas disease
Dicistroviridae
Mathematical model
Passive viral exposure
Triatoma virus
Triatomines
Trypanosoma cruzi
spellingShingle Ciencias Naturales
Ciencias Veterinarias
Ciencias Médicas
Biological control
Chagas disease
Dicistroviridae
Mathematical model
Passive viral exposure
Triatoma virus
Triatomines
Trypanosoma cruzi
Echeverría, María Gabriela
Martí, Gerardo Aníbal
Susevich, María Laura
Rabinovich, Jorge Eduardo
Seroprevalence of <i>Triatoma virus</i> (<i>Dicistroviridae</i>: <i>Cripaviridae</i>) antibodies in Chagas disease patients
topic_facet Ciencias Naturales
Ciencias Veterinarias
Ciencias Médicas
Biological control
Chagas disease
Dicistroviridae
Mathematical model
Passive viral exposure
Triatoma virus
Triatomines
Trypanosoma cruzi
description Background: Chagas disease is caused by <i>Trypanosoma cruzi</i>, and humans acquire the parasite by exposure to contaminated feces from hematophagous insect vectors known as triatomines. Triatoma virus (TrV) is the sole viral pathogen of triatomines, and is transmitted among insects through the fecal-oral route and, as it happens with <i>T. cruzi</i>, the infected insects release the virus when defecating during or after blood uptake. Methods: In this work, we analysed the occurrence of anti-TrV antibodies in human sera from Chagas disease endemic and non-endemic countries, and developed a mathematical model to estimate the transmission probability of TrV from insects to man, which ranged between 0.00053 and 0.0015. Results: Our results confirm that people with Chagas disease living in Bolivia, Argentina and Mexico have been exposed to TrV, and that TrV is unable to replicate in human hosts. Conclusions: We presented the first experimental evidence of antibodies against TrV structural proteins in human sera.
format Articulo
Articulo
author Echeverría, María Gabriela
Martí, Gerardo Aníbal
Susevich, María Laura
Rabinovich, Jorge Eduardo
author_facet Echeverría, María Gabriela
Martí, Gerardo Aníbal
Susevich, María Laura
Rabinovich, Jorge Eduardo
author_sort Echeverría, María Gabriela
title Seroprevalence of <i>Triatoma virus</i> (<i>Dicistroviridae</i>: <i>Cripaviridae</i>) antibodies in Chagas disease patients
title_short Seroprevalence of <i>Triatoma virus</i> (<i>Dicistroviridae</i>: <i>Cripaviridae</i>) antibodies in Chagas disease patients
title_full Seroprevalence of <i>Triatoma virus</i> (<i>Dicistroviridae</i>: <i>Cripaviridae</i>) antibodies in Chagas disease patients
title_fullStr Seroprevalence of <i>Triatoma virus</i> (<i>Dicistroviridae</i>: <i>Cripaviridae</i>) antibodies in Chagas disease patients
title_full_unstemmed Seroprevalence of <i>Triatoma virus</i> (<i>Dicistroviridae</i>: <i>Cripaviridae</i>) antibodies in Chagas disease patients
title_sort seroprevalence of <i>triatoma virus</i> (<i>dicistroviridae</i>: <i>cripaviridae</i>) antibodies in chagas disease patients
publishDate 2015
url http://sedici.unlp.edu.ar/handle/10915/86187
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