Intraluminal administration of poly I:C causes an enteropathy that is exacerbated by administration of oral dietary antigen

Systemic administration of polyinosinic:polycytidylic acid (poly I:C), mimics virally-induced activation of TLR3 signalling causing acute small intestine damage, but whether and how mucosal administration of poly I:C causes enteropathy is less clear. Our aim was to investigate the inflammatory pathw...

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Autores principales: Araya, Romina Elizabeth, Jury, Jennifer, Bondar, Constanza María, Verdu, Elena F., Chirdo, Fernando Gabriel
Formato: Articulo
Lenguaje:Inglés
Publicado: 2014
Materias:
Ciencias Exactas
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/85588
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-85588
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Ciencias Exactas
spellingShingle Ciencias Exactas
Araya, Romina Elizabeth
Jury, Jennifer
Bondar, Constanza María
Verdu, Elena F.
Chirdo, Fernando Gabriel
Intraluminal administration of poly I:C causes an enteropathy that is exacerbated by administration of oral dietary antigen
topic_facet Ciencias Exactas
description Systemic administration of polyinosinic:polycytidylic acid (poly I:C), mimics virally-induced activation of TLR3 signalling causing acute small intestine damage, but whether and how mucosal administration of poly I:C causes enteropathy is less clear. Our aim was to investigate the inflammatory pathways elicited after intraluminal administration of poly I:C and determine acute and delayed consequences of this locally induced immune activation. Intraluminal poly I:C induced rapid mucosal immune activation in C57BL/6 mice involving IFNβ and the CXCL10/CXCR3 axis, that may drive inflammation towards a Th1 profile. Intraluminal poly I:C also caused enteropathy and gut dysfunction in gliadin-sensitive NOD-DQ8 mice, and this was prolonged by concomitant oral administration of gliadin. Our results indicate that small intestine pathology can be induced in mice by intraluminal administration of poly I:C and that this is exacerbated by subsequent oral delivery of a relevant dietary antigen.
format Articulo
Articulo
author Araya, Romina Elizabeth
Jury, Jennifer
Bondar, Constanza María
Verdu, Elena F.
Chirdo, Fernando Gabriel
author_facet Araya, Romina Elizabeth
Jury, Jennifer
Bondar, Constanza María
Verdu, Elena F.
Chirdo, Fernando Gabriel
author_sort Araya, Romina Elizabeth
title Intraluminal administration of poly I:C causes an enteropathy that is exacerbated by administration of oral dietary antigen
title_short Intraluminal administration of poly I:C causes an enteropathy that is exacerbated by administration of oral dietary antigen
title_full Intraluminal administration of poly I:C causes an enteropathy that is exacerbated by administration of oral dietary antigen
title_fullStr Intraluminal administration of poly I:C causes an enteropathy that is exacerbated by administration of oral dietary antigen
title_full_unstemmed Intraluminal administration of poly I:C causes an enteropathy that is exacerbated by administration of oral dietary antigen
title_sort intraluminal administration of poly i:c causes an enteropathy that is exacerbated by administration of oral dietary antigen
publishDate 2014
url http://sedici.unlp.edu.ar/handle/10915/85588
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