The cancer gene WWOX behaves as an inhibitor of SMAD3 transcriptional activity via direct binding

<b>Background:</b> The WW domain containing protein WWOX has been postulated to behave as a tumor suppressor in breast and other cancers. Expression of this protein is lost in over 70% of ER negative tumors. This prompted us to investigate the phenotypic and gene expression effects of lo...

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Detalles Bibliográficos
Autores principales: Ferguson, B. W., Gao, X., Zelazowski, M. J., Lee, J., Jeter, C.R., Abba, Martín Carlos, Aldaz, C. Marcelo
Formato: Articulo
Lenguaje:Inglés
Publicado: 2013
Materias:
Ciencias Médicas
ANGPTL4
Breast Cancer
SMAD3
TGFβ
WWOX
Cáncer
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/85444
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata

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