Hypothalamic IGF-I gene therapy prolongs estrous cyclicity and protects ovarian structure in middle-aged female rats

There is substantial evidence that age-related ovarian failure in rats is preceded by abnormal responsiveness of the neuroendocrine axis to estrogen positive feedback. Because IGF-I seems to act as a permissive factor for proper GnRH neuronal response to estrogen positive feedback and considering th...

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Detalles Bibliográficos
Autores principales: Rodríguez, Silvia Susana, Schwerdt, José Ignacio, Barbeito, Claudio Gustavo, Flamini, Mirta Alicia, Han, Ye, Bohn, Martha, Goya, Rodolfo Gustavo
Formato: Articulo
Lenguaje:Inglés
Publicado: 2013
Materias:
Ciencias Médicas
Terapia génica
Hipotálamo
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/85394
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata

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