Single delivery of an adeno-associated viral construct to transfer the CASQ2 gene to knock-in mice affected by catecholaminergic polymorphic ventricular tachycardia is able to cure the disease from birth to advanced age

Background. Catecholaminergic polymorphic ventricular tachycardia is an inherited arrhythmogenic disorder characterized by sudden cardiac death in children. Drug therapy is still insufficient to provide full protection against cardiac arrest, and the use of implantable defibrillators in the pediatri...

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Detalles Bibliográficos
Autores principales: Denegri, Marco, Bongianino, Rossana, Lodola, Francesco, Boncompagni, Simona, De Giusti, Verónica Celeste, Avelino Cruz, Jossé E., Liu, Nian, Persampieri, Simone, Curcio, Antonio, Esposito, Francesca, Pietrangelo, Laura, Marty, Isabelle, Villani, Laura, Moyaho, Alejandro, Baiardi, Paola, Auricchio, Alberto, Protasi, Feliciano, Napolitano, Carlo, Priori, Silvia G.
Formato: Articulo
Lenguaje:Inglés
Publicado: 2014
Materias:
Ciencias Médicas
Arrhythmias cardiac
Calsequestrin
Death sudden
Genetic therapy
Recovery of function
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/85144
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata

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