Electrostatic complementarity in an aldose reductase complex from ultra-high-resolution crystallography and first-principles calculations

The electron density and electrostatic potential in an aldose reductase holoenzyme complex have been studied by density functional theory (DFT) and diffraction methods. Aldose reductase is involved in the reduction of glucose in the polyol pathway by using NADPH as a cofactor. The ultra-high resolut...

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Detalles Bibliográficos
Autores principales: Muzet, Nicolas, Guillot, Benoît, Jelsch, Christian, Howard, Eduardo Ignacio, Lecomte, Claude
Formato: Articulo
Lenguaje:Inglés
Publicado: 2003
Materias:
Ciencias Exactas
electron density
electrostatic potential
crystallography
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/84550
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata

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