Echocardiographic assessment of left ventricular midwall mechanics in spontaneously hypertensive rats

Aims. The present study was attempted to determine whether LV midwall mechanics yielded different conclusions about LV systolic function than the assessment of endocardial LV mechanics by echocardiography in spontaneously hypertensive rats (SHR). Methods and results. Thirty-six (18 Wistar normoten...

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Autores principales: Escudero, Eduardo Manuel, Camilión de Hurtado, María Cristina, Pérez, Néstor Gustavo, Tufare, Ana Laura
Formato: Articulo
Lenguaje:Inglés
Publicado: 2004
Materias:
Ciencias Médicas
Echocardiography
Left ventricular function
Left ventricular hypertrophy
Midventricular mechanics
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/84464
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-84464
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Ciencias Médicas
Echocardiography
Left ventricular function
Left ventricular hypertrophy
Midventricular mechanics
spellingShingle Ciencias Médicas
Echocardiography
Left ventricular function
Left ventricular hypertrophy
Midventricular mechanics
Escudero, Eduardo Manuel
Camilión de Hurtado, María Cristina
Pérez, Néstor Gustavo
Tufare, Ana Laura
Echocardiographic assessment of left ventricular midwall mechanics in spontaneously hypertensive rats
topic_facet Ciencias Médicas
Echocardiography
Left ventricular function
Left ventricular hypertrophy
Midventricular mechanics
description Aims. The present study was attempted to determine whether LV midwall mechanics yielded different conclusions about LV systolic function than the assessment of endocardial LV mechanics by echocardiography in spontaneously hypertensive rats (SHR). Methods and results. Thirty-six (18 Wistar normotensive (W), 18 [SHR]) anesthetized rats were studied with two-dimensional directed M-mode echocardiogram to analyze LV structure (LV diameter, left ventricular wall thickness and LV mass [LVM]) and LV function (endocardial shortening [ES] and midwall shortening [MS]). Measurements were made from three consecutive cardiac cycles on the M-mode tracings. There was no significant difference in LV dimension. LVM was higher in SHR (SHR: 595 ± 111 mg, W: 413 ± 83 mg - p < 0.01). ES was higher in SHR (SHR: 64.1 ± 6%, w: 58.2 ± 4% - p < 0.01), whereas no significant difference was found in MS (SHR: 27 ± 4%, W: 27.6 ± 4% - ns). Twelve of 18 (66%) SHR showed endocardial shortening higher than normally predicted, compared with 3/18 (16%) with observed enhanced MS (p < 0.01). Conclusion. These results suggest that the analysis of midwall mechanics by echo allows us to better understand the LV performance in SHR and that the exaggerated endocardial motion could not represent a really <i>supernormal</i> systolic performance.
format Articulo
Articulo
author Escudero, Eduardo Manuel
Camilión de Hurtado, María Cristina
Pérez, Néstor Gustavo
Tufare, Ana Laura
author_facet Escudero, Eduardo Manuel
Camilión de Hurtado, María Cristina
Pérez, Néstor Gustavo
Tufare, Ana Laura
author_sort Escudero, Eduardo Manuel
title Echocardiographic assessment of left ventricular midwall mechanics in spontaneously hypertensive rats
title_short Echocardiographic assessment of left ventricular midwall mechanics in spontaneously hypertensive rats
title_full Echocardiographic assessment of left ventricular midwall mechanics in spontaneously hypertensive rats
title_fullStr Echocardiographic assessment of left ventricular midwall mechanics in spontaneously hypertensive rats
title_full_unstemmed Echocardiographic assessment of left ventricular midwall mechanics in spontaneously hypertensive rats
title_sort echocardiographic assessment of left ventricular midwall mechanics in spontaneously hypertensive rats
publishDate 2004
url http://sedici.unlp.edu.ar/handle/10915/84464
work_keys_str_mv AT escuderoeduardomanuel echocardiographicassessmentofleftventricularmidwallmechanicsinspontaneouslyhypertensiverats
AT camiliondehurtadomariacristina echocardiographicassessmentofleftventricularmidwallmechanicsinspontaneouslyhypertensiverats
AT pereznestorgustavo echocardiographicassessmentofleftventricularmidwallmechanicsinspontaneouslyhypertensiverats
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