Floating gellan-chitosan polyelectrolyte complex beads: effect of gelucires incorporation on encapsulation efficiency and drug release
The purpose of the present investigation is to study the effect of incorporation of gelucire 39/01 and 50/13 on encapsulation efficiency and release of water soluble drug (metronidazole, log P = 0.0) from floating gellan-chitosan polyelectrolyte complex (PEC) beads. Floating emulsion PEC beds were p...
Guardado en:
| Autores principales: | , , , , |
|---|---|
| Formato: | Articulo |
| Lenguaje: | Inglés |
| Publicado: |
2012
|
| Materias: | |
| Acceso en línea: | http://sedici.unlp.edu.ar/handle/10915/8426 http://www.latamjpharm.org/resumenes/31/1/LAJOP_31_1_1_6.pdf |
| Aporte de: |
| Sumario: | The purpose of the present investigation is to study the effect of incorporation of gelucire 39/01 and 50/13 on encapsulation efficiency and release of water soluble drug (metronidazole, log P = 0.0) from floating gellan-chitosan polyelectrolyte complex (PEC) beads. Floating emulsion PEC beds were prepared in one step without using any chemical crosslinker. Briefly, an emulsion of gellan gum (GG) with gelucire 39/01 and 50/13 containing CaCO<sub>3</sub> and drug was extruded dropwise into low molecular weight chitosan (LMCH) solution. Beads formed instantaneously were cured for 15 min at elevated temperature (37 °C). Prepared beads showed excellent buoyancy along with significantly improved encapsulation efficiency and sustained release of metronidazole when compared to floating gellan-chitosan PEC beads prepared in the similar manner but without gelucires. Experimental data obtained from the present investigation showed that floating emulsion PEC beads may form a potential stomach site specific drug delivery system for the delivery of highly water soluble drugs with an absorption window in the upper gastrointestinal tract. |
|---|