Synthesis and evaluation of the antifungal activity of 2-(substituted-amino)-4,5-dialkyl-thiophene-3- carbonitrile derivatives

Fifteen 2-[(substituted-benzylidene)-amino]-5-methyl-thiophene-3-carbonitrile (3a-g) and 2-[(substituted-benzylidene)-amino]-4,5-cycloalkyl-thiophene-3-carbonitrile derivatives (4a-h) were synthesized and screened for their in vitro antifungal activity against 42 clinical isolates of Candida (repres...

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Detalles Bibliográficos
Autores principales: Mendonça Jr., Francisco J. B., Lima, María do Carmo A., Lima Neto, Reginaldo G., Oliveira, Tiago B., Pitta, Iván R., Galdino, Suely L., Cruz, Rayssa M.D. da, Araújo, Rodrigo S. A. de, Neves, Rejane P.
Formato: Articulo
Lenguaje:Inglés
Publicado: 2011
Materias:
Farmacia
antifungal activity; candida; criptococcus neoformans; gewald reaction; minimal fungicidal concentration; thiophene derivatives
Agentes Antifúngicos
Hongos
Levaduras
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/8329
http://www.latamjpharm.org/resumenes/30/8/LAJOP_30_8_1_6.pdf
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata

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