Genistein suppresses doxorubicin associated genotoxicity in human lymphocytes

Doxorubicin is a well-known DNA intercalating chemotherapy drug that is widely used for treatment of different cancers. Its clinical utility is limited due to the observed genotoxic side effects on healthy cells suggesting that newer combination and genoprotective regimens are urgently needed for th...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Beg, Tanveer, Siddique, Yasir H., Ara, Gulshan, Afzal, Mohammad, Azmi, Asfar S.
Formato:	Articulo
Lenguaje:	Inglés
Publicado:	2011
Materias:	Farmacia apoptosis; DNA damage markers; doxorubicin; genistein; genotoxicity; human lymphocyte culture cáncer Isoflavonas Daunorrubicina Toxicidad
Acceso en línea:	http://sedici.unlp.edu.ar/handle/10915/8300 http://www.latamjpharm.org/resumenes/30/7/LAJOP_30_7_1_10.pdf
Aporte de:	SEDICI (UNLP) de Universidad Nacional de La Plata

id	I19-R120-10915-8300
record_format	dspace
institution	Universidad Nacional de La Plata
institution_str	I-19
repository_str	R-120
collection	SEDICI (UNLP)
language	Inglés
topic	Farmacia apoptosis; DNA damage markers; doxorubicin; genistein; genotoxicity; human lymphocyte culture cáncer Isoflavonas Daunorrubicina Toxicidad
spellingShingle	Farmacia apoptosis; DNA damage markers; doxorubicin; genistein; genotoxicity; human lymphocyte culture cáncer Isoflavonas Daunorrubicina Toxicidad Beg, Tanveer Siddique, Yasir H. Ara, Gulshan Afzal, Mohammad Azmi, Asfar S. Genistein suppresses doxorubicin associated genotoxicity in human lymphocytes
topic_facet	Farmacia apoptosis; DNA damage markers; doxorubicin; genistein; genotoxicity; human lymphocyte culture cáncer Isoflavonas Daunorrubicina Toxicidad
description	Doxorubicin is a well-known DNA intercalating chemotherapy drug that is widely used for treatment of different cancers. Its clinical utility is limited due to the observed genotoxic side effects on healthy cells suggesting that newer combination and genoprotective regimens are urgently needed for the management of doxorubicin chemotherapy. Some dietary phytochemicals are well known for their protective mechanism of action and genistein from soy is recognized as an anti-oxidant with similar properties. Therefore, the present study investigates the effect of genistein against the genotoxic doses of doxorubicin by assessing chromosomal aberrations, sister chromatid exchanges, cell cycle kinetics, cell viability, apoptosis, and DNA damage markers in cultured human lymphocytes. Our results reveal that genistein treatment significantly suppresses genotoxic damage induced by doxorubicin. It is concluded that genistein has the potential to reduce the genotoxicity induced by anti-cancer drugs, thereby reducing the chances of developing secondary tumors during the therapy.
format	Articulo Articulo
author	Beg, Tanveer Siddique, Yasir H. Ara, Gulshan Afzal, Mohammad Azmi, Asfar S.
author_facet	Beg, Tanveer Siddique, Yasir H. Ara, Gulshan Afzal, Mohammad Azmi, Asfar S.
author_sort	Beg, Tanveer
title	Genistein suppresses doxorubicin associated genotoxicity in human lymphocytes
title_short	Genistein suppresses doxorubicin associated genotoxicity in human lymphocytes
title_full	Genistein suppresses doxorubicin associated genotoxicity in human lymphocytes
title_fullStr	Genistein suppresses doxorubicin associated genotoxicity in human lymphocytes
title_full_unstemmed	Genistein suppresses doxorubicin associated genotoxicity in human lymphocytes
title_sort	genistein suppresses doxorubicin associated genotoxicity in human lymphocytes
publishDate	2011
url	http://sedici.unlp.edu.ar/handle/10915/8300 http://www.latamjpharm.org/resumenes/30/7/LAJOP_30_7_1_10.pdf
work_keys_str_mv	AT begtanveer genisteinsuppressesdoxorubicinassociatedgenotoxicityinhumanlymphocytes AT siddiqueyasirh genisteinsuppressesdoxorubicinassociatedgenotoxicityinhumanlymphocytes AT aragulshan genisteinsuppressesdoxorubicinassociatedgenotoxicityinhumanlymphocytes AT afzalmohammad genisteinsuppressesdoxorubicinassociatedgenotoxicityinhumanlymphocytes AT azmiasfars genisteinsuppressesdoxorubicinassociatedgenotoxicityinhumanlymphocytes
bdutipo_str	Repositorios
_version_	1764820488158183427

Genistein suppresses doxorubicin associated genotoxicity in human lymphocytes

Ejemplares similares