Compatibility studies of Olanzapine pre-formulated with excipients by thermal analysis: preliminary study

Thermogravimetric analysis (TGA) and differential scanning calorimetry (DSC) were used to investigate drug-excipient interactions and, in consequence, their compatibility. For this purpose, binary mixtures of olanzapine drug substance and the excipients croscarmellose sodium, magnesium stearate and...

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Detalles Bibliográficos
Autores principales: Marques, Lucas M. M., Medeiros, Maria G. F. de, Nunes, Lívio C. C., Citó, Antônia M.G.L., Lopes, José A. D., Souza, Alexandre A., Souza, Claide M. L.
Formato: Articulo Comunicacion
Lenguaje:Inglés
Publicado: 2011
Materias:
Farmacia
Excipientes Farmacéuticos
compatibility; DSC; excipient; olanzapine; TGA; thermal analysis
Técnicas de Química Analítica
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/8283
http://www.latamjpharm.org/resumenes/30/6/LAJOP_30_6_2_2.pdf
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
Descripción
Sumario:Thermogravimetric analysis (TGA) and differential scanning calorimetry (DSC) were used to investigate drug-excipient interactions and, in consequence, their compatibility. For this purpose, binary mixtures of olanzapine drug substance and the excipients croscarmellose sodium, magnesium stearate and microcrystalline cellulose, were prepared and analysed. By the analysis of the binary mixtures DSC and TG curves it were observed changes on the temperature and enthalpy values of the drug melting and decomposition peak, with the likely formation of intermediate substances.

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