In vitro and in vivo antitumor effects of the flavonol glycosides isolated of Herissantia crispa (L.) Brizicky

This paper describes the cytotoxic and antitumoral activities of kaempferol 3-O-(6”-O-E-pcoumaroyl)-β-D-glucopyranoside (tiliroside), kaempferol 3,7-di-O-α-L-rhamnoside (dhiramnoside) and of the mixture of sitosteryl-3-O-β-D-glucopyranoside and stigmasteryl-3-O-β-D-glucopyranoside (GM) isolated of t...

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Detalles Bibliográficos
Autores principales: Carvalho, Paulo R. C., Aguiar, Jaciana S., Matias, Wemerson N., Gomes, Roosevelt A., Teles, Yanna C.F., Souza, Maria de F. V., Medeiros, Paloma L., Silva, Eliete C., Silva, Teresinha G., Carneiro do Nascimento, Silene
Formato: Articulo
Lenguaje:Inglés
Publicado: 2011
Materias:
Farmacia
antitumor activity; flavonol; glycosides; Herissantia crispa
Plantas Medicinales
Pruebas de Toxicidad
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/8131
http://www.latamjpharm.org/resumenes/30/2/LAJOP_30_2_1_6.pdf
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
Descripción
Sumario:This paper describes the cytotoxic and antitumoral activities of kaempferol 3-O-(6”-O-E-pcoumaroyl)-β-D-glucopyranoside (tiliroside), kaempferol 3,7-di-O-α-L-rhamnoside (dhiramnoside) and of the mixture of sitosteryl-3-O-β-D-glucopyranoside and stigmasteryl-3-O-β-D-glucopyranoside (GM) isolated of the Herissantia crispa. The compounds did not present cytotoxic activity against NCI-H292, HEp-2 and KB cells. In vivo, dhiramnoside did not present significant inhibitory activity of the growth of sarcoma 180 when compared with the control group; however, tiliroside and GM-treated animals showed a high inhibition rate in the growth of the tumor. Tiliroside inhibits significantly the growth of the carcinoma of Ehrlich. In conclusion, tiliroside exhibited promising antitumor effects without an expressive toxicity.

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