In vitro cytotoxicity and antibacterial activities of cephalosporin tin(II) complexes

Cytotoxicity and antibacterial activities of three novel tin(II) complexes containing cephalosporins: [Sn(cephalothin)Cl], [Sn(cephradine)Cl].H<sub>2</sub>O and [Sn(cefotaxime)Cl].H<sub>2</sub>O were investigated against Artemia salina (brine shrimp) and four bacterial stra...

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Autores principales: Anacona, Juan R., Brito, Liangel
Formato: Articulo Comunicacion
Lenguaje:Inglés
Publicado: 2011
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Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/8118
http://www.latamjpharm.org/resumenes/30/1/LAJOP_30_1_2_2.pdf
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Sumario:Cytotoxicity and antibacterial activities of three novel tin(II) complexes containing cephalosporins: [Sn(cephalothin)Cl], [Sn(cephradine)Cl].H<sub>2</sub>O and [Sn(cefotaxime)Cl].H<sub>2</sub>O were investigated against Artemia salina (brine shrimp) and four bacterial strains. The results were compared with the activity of free cephalosporins. The coordination of cephalothin and cephradine to tin(II) ion showed an enhancement of the antibacterial activity