Physicochemical characterization of La<sub>2</sub>(CO<sub>3</sub>)<sub>3</sub>.4H<sub>3</sub>O, a new and promising agent for the treatment of hyperphosphatemia

The synthesis of La<sub>2</sub>(CO<sub>3</sub>)<sub>3</sub>.4H<sub>2</sub>O was carefully investigated, on the basis of the thermal behavior (TG and DTA measurements) of the corresponding octahydrate, used as the precursor. The analysis of the X-ray po...

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Detalles Bibliográficos
Autor principal:	Barán, Enrique José
Formato:	Articulo
Lenguaje:	Inglés
Publicado:	2011
Materias:	Farmacia Trastornos del Metabolismo del Fósforo Cristalografía Lantano crystallographic data; hyperphosphatemia; lanthanum carbonate tetrahydrate; thermal behavior; vibrational spectra
Acceso en línea:	http://sedici.unlp.edu.ar/handle/10915/8111 http://www.latamjpharm.org/resumenes/30/1/LAJOP_30_1_1_19.pdf
Aporte de:	SEDICI (UNLP) de Universidad Nacional de La Plata

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Sumario:	The synthesis of La<sub>2</sub>(CO<sub>3</sub>)<sub>3</sub>.4H<sub>2</sub>O was carefully investigated, on the basis of the thermal behavior (TG and DTA measurements) of the corresponding octahydrate, used as the precursor. The analysis of the X-ray powder diagrams of La<sub>2</sub>(CO<sub>3</sub>)<sub>3</sub>.4H<sub>2</sub>O showed that this hydrate crystallizes in the tetragonal crystal system with Z = 8. The FTIR and FT-Raman spectra of La<sub>2</sub>(CO<sub>3</sub>)<sub>3</sub>.4H<sub>2</sub>O and of La<sub>2</sub>(CO<sub>3</sub>)<sub>3</sub>.4H<sub>2</sub>O were recorded and assigned. The usefulness of the tetrahydrate for the treatment of hyperphosphatemia is briefly discussed.