Prodrug design of NSAIDs: synthesis and pharmacological profiles of amide prodrugs of etodolac with amino acids
Novel amide prodrugs of etodolac with various amino acids were synthesized and the structures were confirmed by elemental and spectral analyses. In vitro hydrolytic studies in various simulated fluids confirmed the hydrolysis of prodrugs in colon. The prodrugs showed an improved anti-inflammatory...
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| Autores principales: | Rasheed, Arun, Kumar, C.K. Ashok, Ravichandran, V., Purushothaman, M. |
|---|---|
| Formato: | Articulo |
| Lenguaje: | Inglés |
| Publicado: |
2011
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| Materias: | |
| Acceso en línea: | http://sedici.unlp.edu.ar/handle/10915/8103 http://www.latamjpharm.org/resumenes/30/1/LAJOP_30_1_1_11.pdf |
| Aporte de: |
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