Physicochemical characterization and improved in vitro dissolution performance of diacerein solid dispersions with PVP K30

Solid dispersions (SDs) of poorly water soluble diacerein were prepared with polyvinylpyrrolidone K30 at drug to polymer ratios of 1:1, 1:3 and 1:5 w/w utilizing kneading technique. Physical mixture (PM) was prepared at drug to polymer ratio of 1:5 w/w for comparison. All formulations were further c...

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Detalles Bibliográficos
Autores principales: Patil, Snehal B., Shete, Tushar K., Narade, Sarika B., Surve, Sharda S., Khan, Ziya K., Bhokare, Kuldeep K., Pore, Yogesh V.
Formato: Articulo
Lenguaje:Inglés
Publicado: 2011
Materias:
Farmacia
caracterización; diacereína; disolución; povidona K30; dispersión sólida
characterization; diacerein,; dissolution; polyvinylpyrrolidone K30; solid dispersion
caracterização; diacereína; dissolução; polivinilpirrolidona K30; dispersão dos sólidos
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/8100
http://www.latamjpharm.org/resumenes/30/1/LAJOP_30_1_1_9.pdf
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata

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