Extended hildebrand solubility approach in the solubility estimation of the sunscreen ethylhexyl triazone in ethyl acetate + ethanol mixtures
Ethylhexyl triazone (EHT) is a sunscreen agent widely used in the formulation of skin care products, whose physicochemical properties have not been thoroughly studied. In this work the Extended Hildebrand Solubility Approach (EHSA) was applied to evaluate the solubility of EHT in ethyl acetate +...
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| Autores principales: | , , , , |
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| Formato: | Articulo |
| Lenguaje: | Inglés |
| Publicado: |
2010
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| Materias: | |
| Acceso en línea: | http://sedici.unlp.edu.ar/handle/10915/8036 http://www.latamjpharm.org/resumenes/29/7/LAJOP_29_7_1_9.pdf |
| Aporte de: |
| Sumario: | Ethylhexyl triazone (EHT) is a sunscreen agent widely used in the formulation of skin care
products, whose physicochemical properties have not been thoroughly studied. In this work the Extended
Hildebrand Solubility Approach (EHSA) was applied to evaluate the solubility of EHT in ethyl acetate +
ethanol mixtures at 298.15 K. A good correlative capacity of EHSA was found using a regular polynomial
model in order five (overall deviation lower than 1.2 %), when the W interaction parameter is related to
the solubility parameter of the mixtures. Besides, the deviations obtained in the estimated solubility with
respect to experimental solubility were lower compared with those obtained directly by means of an empiric
regression of the experimental solubility as a function of the mixtures' solubility parameters. |
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