Genotoxic effect of aqueous extracts from South American Achyrocline and Gnaphalium species (Asteraceae: Gnaphalieae) on human lymphocytes

Crude drug and different extracts of Achyrocline satureioides (Lam.) DC., A. tomentosa Rusby, Gnaphalium cheiranthifolium Lam. and G. gaudichaudianum DC. (Gnaphalieae: Asteraceae) are widely used in South America mainly as digestives and hepatics. These are raw material for phytotherapics preparatio...

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Autores principales: Carballo, Marta A., Cortada, Catalina M., Gadano, Andrea B., Del Vitto, Luis A., Petenatti, Elisa M.
Formato: Articulo
Lenguaje:Inglés
Publicado: 2010
Materias:
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/8032
http://www.latamjpharm.org/resumenes/29/7/LAJOP_29_7_1_5.pdf
Aporte de:SEDICI (UNLP) de Universidad Nacional de La Plata Ver origen
id I19-R120-10915-8032
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spelling I19-R120-10915-80322019-06-30T04:02:36Z http://sedici.unlp.edu.ar/handle/10915/8032 http://www.latamjpharm.org/resumenes/29/7/LAJOP_29_7_1_5.pdf Genotoxic effect of aqueous extracts from South American Achyrocline and Gnaphalium species (Asteraceae: Gnaphalieae) on human lymphocytes Carballo, Marta A. Cortada, Catalina M. Gadano, Andrea B. Del Vitto, Luis A. Petenatti, Elisa M. 2010 2010-11-08T03:00:00Z en Farmacia Achyrocline; comet assay; DNA damage; genotoxicity; gnaphalium Crude drug and different extracts of Achyrocline satureioides (Lam.) DC., A. tomentosa Rusby, Gnaphalium cheiranthifolium Lam. and G. gaudichaudianum DC. (Gnaphalieae: Asteraceae) are widely used in South America mainly as digestives and hepatics. These are raw material for phytotherapics preparations and the manufacture of traditional bitter drinks. In order to establish some aspects on their safety, we have evaluated four different concentrations (1, 10, 100, and 1000 µL.mL-1) of the aqueous extracts of these plants against Single Cell Gel Electrophoresis Assay (SCGEA) in human peripheral blood lymphocytes. Results show a significant increase in damage index (p < 0.001) for all aqueous extracts concentrations assayed of the four plant species, in relation to negative control values. This is a contribution to the development of screenings related to the potential health risk associated with the consumption of South American medicinal plants, especially taking in mind that these plants are widely used as over-thecounter herbs. Colegio de Farmacéuticos de la Provincia de Buenos Aires Articulo Articulo application/pdf 1088-1092
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Farmacia
Achyrocline; comet assay; DNA damage; genotoxicity; gnaphalium
spellingShingle Farmacia
Achyrocline; comet assay; DNA damage; genotoxicity; gnaphalium
Carballo, Marta A.
Cortada, Catalina M.
Gadano, Andrea B.
Del Vitto, Luis A.
Petenatti, Elisa M.
Genotoxic effect of aqueous extracts from South American Achyrocline and Gnaphalium species (Asteraceae: Gnaphalieae) on human lymphocytes
topic_facet Farmacia
Achyrocline; comet assay; DNA damage; genotoxicity; gnaphalium
description Crude drug and different extracts of Achyrocline satureioides (Lam.) DC., A. tomentosa Rusby, Gnaphalium cheiranthifolium Lam. and G. gaudichaudianum DC. (Gnaphalieae: Asteraceae) are widely used in South America mainly as digestives and hepatics. These are raw material for phytotherapics preparations and the manufacture of traditional bitter drinks. In order to establish some aspects on their safety, we have evaluated four different concentrations (1, 10, 100, and 1000 µL.mL-1) of the aqueous extracts of these plants against Single Cell Gel Electrophoresis Assay (SCGEA) in human peripheral blood lymphocytes. Results show a significant increase in damage index (p < 0.001) for all aqueous extracts concentrations assayed of the four plant species, in relation to negative control values. This is a contribution to the development of screenings related to the potential health risk associated with the consumption of South American medicinal plants, especially taking in mind that these plants are widely used as over-thecounter herbs.
format Articulo
Articulo
author Carballo, Marta A.
Cortada, Catalina M.
Gadano, Andrea B.
Del Vitto, Luis A.
Petenatti, Elisa M.
author_facet Carballo, Marta A.
Cortada, Catalina M.
Gadano, Andrea B.
Del Vitto, Luis A.
Petenatti, Elisa M.
author_sort Carballo, Marta A.
title Genotoxic effect of aqueous extracts from South American Achyrocline and Gnaphalium species (Asteraceae: Gnaphalieae) on human lymphocytes
title_short Genotoxic effect of aqueous extracts from South American Achyrocline and Gnaphalium species (Asteraceae: Gnaphalieae) on human lymphocytes
title_full Genotoxic effect of aqueous extracts from South American Achyrocline and Gnaphalium species (Asteraceae: Gnaphalieae) on human lymphocytes
title_fullStr Genotoxic effect of aqueous extracts from South American Achyrocline and Gnaphalium species (Asteraceae: Gnaphalieae) on human lymphocytes
title_full_unstemmed Genotoxic effect of aqueous extracts from South American Achyrocline and Gnaphalium species (Asteraceae: Gnaphalieae) on human lymphocytes
title_sort genotoxic effect of aqueous extracts from south american achyrocline and gnaphalium species (asteraceae: gnaphalieae) on human lymphocytes
publishDate 2010
url http://sedici.unlp.edu.ar/handle/10915/8032
http://www.latamjpharm.org/resumenes/29/7/LAJOP_29_7_1_5.pdf
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