Calcium-calmodulin-dependent protein kinase mediates the intracellular signalling pathways of cardiac apoptosis in mice with impaired glucose tolerance

The impact of cardiac apoptosis in pre-diabetic stages of diabetic cardiomyopathy is unknown. We show that myocytes from fructose-rich diet (FRD) animals exhibit arrhythmias produced by exacerbated Ca2+/calmodulin-protein kinase (CaMKII) activity, ryanodine receptor 2 (RyR2) phosphorylation and sarc...

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Detalles Bibliográficos
Autores principales: Federico, Marilén, Portiansky, Enrique Leo, Sommese, Leandro Matías, Alvarado, Francisco J., Blanco, Paula Graciela, Zanuzzi, Carolina Natalia, Dedman, John, Kaetzel, Marcia, Wehrens, Xander H. T, Mattiazzi, Alicia, Palomeque, Julieta
Formato: Articulo
Lenguaje:Inglés
Publicado: 2017
Materias:
Ciencias Médicas
cardiac apoptosis
diabetic cardiomyopathy
fructose-rich diet
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/80286
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata

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