High throughput simultaneous assay of atenolol and chlortalidone in combined dose tablets by liquid chromatography and capillary zone electrophoresis

New fast liquid chromatographic and capillary zone electrophoresis methods were developed and validated for simultaneous determination of atenolol and chlortalidone in combined dose tablets. The reversed phase HPLC method was carried out on a CN LiChrosorb® (125 x 4 mm, 5 μm) column. The CZE method...

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Detalles Bibliográficos
Autores principales: Patto, Daniela C.S., Leite, Heitor O.A., Tavares, Vanessa F., Almeida, Mariana M. de, Lima, Cibele R. R. C., Alves, João M. P., Prado, Maria S. A., Hackmann, Erika R. M. K., Santoro, Maria Ines Rocha Miritello, Singh, Anil K.
Formato: Articulo
Lenguaje:Inglés
Publicado: 2010
Materias:
Farmacia
Farmacología
atenolol; capillary zone electrophoresis; chlortalidone; liquid chromatography quantitative determination
Cromatografía líquida
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/7953
http://www.latamjpharm.org/resumenes/29/4/LAJOP_29_4_1_16.pdf
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
Descripción
Sumario:New fast liquid chromatographic and capillary zone electrophoresis methods were developed and validated for simultaneous determination of atenolol and chlortalidone in combined dose tablets. The reversed phase HPLC method was carried out on a CN LiChrosorb® (125 x 4 mm, 5 μm) column. The CZE method was carried out on an uncoated fused-silica capillary of 30 cm x 75 μm i.d. with 25 mmol L<sup>-1</sup> sodium tetraborate, pH 9.4. The total analysis time was <6 and <2.5 min for HPLC and CZE methods, respectively. Both methods can be used for stability studies as well.

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