Pharmacokinetics, tissue distribution and bioavailability of imatinib in mice after administration of a single oral and an intravenous bolus dose

Imatinib inhibits Bcr-Abl, c-KIT and PDGFR kinases involved in chronic myelogenous leukemia and gastrointestinal stromal tumors. Mice were given imatinib PO (50 mg/kg) or IV (12.5 mg/kg) and plasma, liver, brain, spleen, kidney disposition profiles analyzed. Plasma t1/2 was 4.5 h. IV plasma AUC0→∞ w...

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Detalles Bibliográficos
Autores principales: Teoh, Magdalene, Radhakrishnan, Shantini, Moo, Kai S., Narayanan, Prasad, Bukhari, Nadeem I., Segarra, Ignacio
Formato: Articulo
Lenguaje:Inglés
Publicado: 2010
Materias:
Farmacia
Leucemia Mieloide
bioavailability; chronic myeloid leukemia; gastrointestinal stromal tumor; imatinib; pharmacokinetics;tissue distribution
Farmacocinética
Distribución Tisular
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/7928
http://www.latamjpharm.org/resumenes/29/3/LAJOP_29_3_1_15.pdf
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata

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