Calendula officinalis: Efeito depressor central e toxicidade subaguda
Flowers of Calendula officinalis L. (calendula) have been popularly used due to some attributed medicinal properties as wound healing, anti-inflammatory and sedative activites. The principal chemical compounds found in flowers are essential oils, salicilic acid, carotenoids, flavonoids, tannins a...
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| Autores principales: | , , , , , , |
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| Formato: | Articulo |
| Lenguaje: | Portugués |
| Publicado: |
2009
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| Materias: | |
| Acceso en línea: | http://sedici.unlp.edu.ar/handle/10915/7853 http://www.latamjpharm.org/trabajos/28/6/LAJOP_28_6_1_15_605YIUZ4G2.pdf |
| Aporte de: |
| Sumario: | Flowers of Calendula officinalis
L. (calendula) have been popularly used due to some attributed medicinal properties as wound healing,
anti-inflammatory and sedative activites. The principal chemical compounds found in flowers are essential oils,
salicilic acid, carotenoids, flavonoids, tannins and triterpenic saponins.Other medicinal plants that present
flavonoids in his composition have also been used as ansiolitic and analgesic. In this work the activity of calendula
was evaluated on the central nervous system, with models of sleep induced by barbiturates, rota rod and
open field. Subacute toxicity was evaluated in rats in metabolic cages. Central depressive effect was observed,
with decrease of the spontaneous movement. Hypoglycemic effect was observed but signs of subcute toxicity
were not evidenced. |
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