Toxicidade pré-clínica de fitoterápico contendo Gentiana lutea, Rheum palmatum, Aloe ferox, Cynara scolymus, Atropa belladona, Peumus boldus e Baccharis trimera em Coelhos Nova Zelândia
The phytotherapic formulation constituted by Gentiana lutea (genciana), Rheum palmatum (ruibarbo), Aloe ferox (aloé), Cynara scolymus (alcachofra), Atropa belladona (beladona), Paumus boldus (boldo) and Baccharis trimera (carqueja) (Gotas Preciosas®) was investigated from the potential of toxicolo...
Guardado en:
| Autores principales: | , , |
|---|---|
| Formato: | Articulo Comunicacion |
| Lenguaje: | Portugués |
| Publicado: |
2008
|
| Materias: | |
| Acceso en línea: | http://sedici.unlp.edu.ar/handle/10915/7682 http://www.latamjpharm.org/trabajos/27/5/LAJOP_27_5_2_1_8SB0766R51.pdf |
| Aporte de: |
| Sumario: | The phytotherapic formulation constituted by Gentiana lutea (genciana), Rheum palmatum (ruibarbo), Aloe
ferox (aloé), Cynara scolymus (alcachofra), Atropa belladona (beladona), Paumus boldus (boldo) and Baccharis
trimera (carqueja) (Gotas Preciosas®) was investigated from the potential of toxicological effects when orally
administered for 30 days to male and female New Zealand rabbits. The daily oral dose was ten times the prescribed
dosage to humans. The general signs of toxicity, locomotion, behavior, respiratory rate and rhythm were
evaluated. Body weight, food and water intake, rectal temperature, hematological and biochemical blood analysis,
urinalysis, anatomopathological evaluation and visceral weight were measured. The results interpreted as a
whole revealed the absence of toxicological effects to the phytotherapic investigated when administered to New
Zealand rabbits in a dose equivalent to 10 times the human dose. The phytotherapic can be considered relatively
innocuous. |
|---|