QSPR studies on aqueous solubilities of drug-like compounds

A rapidly growing area of modern pharmaceutical research is the prediction of aqueous solubility of drug-sized compounds from their molecular structures. There exist many different reasons for considering this physico-chemical property as a key parameter: the design of novel entities with adequate a...

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Detalles Bibliográficos
Autores principales:	Duchowicz, Pablo Román, Castro, Eduardo A.
Formato:	Articulo Revision
Lenguaje:	Inglés
Publicado:	2009
Materias:	Ciencias Exactas Química clinical research ADME/Tox properties aqueous solubility computer model group contribution methods physical chemistry quantitative structure property relation high throughput screening techniques Lipinski rules thermodynamics molecular descriptors QSPR theory replacement method
Acceso en línea:	http://sedici.unlp.edu.ar/handle/10915/37728 http://www.mdpi.com/1422-0067/10/6/2558
Aporte de:	SEDICI (UNLP) de Universidad Nacional de La Plata

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