Human apolipoprotein A-I natural variants: molecular mechanisms underlying amyloidogenic propensity

Human apolipoprotein A-I (apoA-I)-derived amyloidosis can present with either wild-type (Wt) protein deposits in atherosclerotic plaques or as a hereditary form in which apoA-I variants deposit causing multiple organ failure. More than 15 single amino acid replacement amyloidogenic apoA-I variants h...

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Detalles Bibliográficos
Autores principales:	Ramella, Nahuel Alberto, Schinella, Guillermo, Ferreira, Sergio T., Prieto, Eduardo Daniel, Vela, María Elena, Ríos, José Luis, Tricerri, María Alejandra, Rimoldi, Omar Jorge
Formato:	Articulo
Lenguaje:	Inglés
Publicado:	2012
Materias:	Ciencias Médicas Medicina macrophage activation polyneuropathy protein aggregation Amino Acid Substitution Amyloidogenic Proteins Protein Folding Protein Multimerization Protein Stability
Acceso en línea:	http://sedici.unlp.edu.ar/handle/10915/34069 http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0043755
Aporte de:	SEDICI (UNLP) de Universidad Nacional de La Plata

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